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Mekambo is a small town in north-eastern Gabon on the banks of the Zadié river. It is located in the Ogooué-Ivindo province of Gabon and is the seat of the Zadié Department. It has received international press for recent outbreaks of Ebola hemorrhagic fever in 1994 and 1997.
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Mekambo's climate is classified as tropical. The winter months are much rainier than the summer months in Mekambo. The Koppen-Geiger climate classification is As. The average temperature in Mekambo is 23.8 °C. The average annual rainfall is 1583 mm.