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Mytilene is a city founded in the 11th century BC. Mytilene is the capital city and port of the island of Lesbos and also the capital of the North Aegean Region. The seat of the governor of the North Aegean Region is Mytilene. Mytilene is also one of 13 municipalities (counties) on the island of Lesbos. Mytilene is built on the southeast edge of the island. It is also the seat of a metropolitan bishop of the Eastern Orthodox Church.
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The climate is warm and temperate in Mytilene. The rain in Mytilene falls mostly in the winter, with relatively little rain in the summer. This climate is considered to be Csa according to the Koppen-Geiger climate classification. The temperature here averages 17.3 °C. In a year, the average rainfall is 647 mm.